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Accuracy of a new MRI-based patient-individual stereotactic brain biopsy device in the dog

Presentation held at 30th Annual Symposium of the ESVN-ECVN, Geriatric veterinary neurology, 21-23 September 2017, Helsinki
: Hanemann, Sarah; Winkler, Dirk; Müller, Marcel; Möbius, Robert; Fischer, Jean-Pierre; Böttcher, Peter; Kiefer, Ingmar; Grunert, Ronny; Flegel, Thomas

Präsentation urn:nbn:de:0011-n-4733348 (1.6 MByte PDF)
MD5 Fingerprint: 87b696388e1a4cef5657311a53a703ca
Erstellt am: 11.11.2017

2017, 11 Folien
European Society of Veterinary Neurology - European College of Veterinary Neurology (ESVN-ECVN Annual Symposium) <30, 2017, Helsinki>
Vortrag, Elektronische Publikation
Fraunhofer IWU ()
canine brain biopsy; patient-individual; MRI-based; stereotactic

Brain biopsy of intracranial lesions is often necessary in order to determine specific therapy. Complexity and vulnerability of the brain, however, require high accuracy during needle placement. The aim of the study was to determine the precision of the new MRI-based patient-individual stereotactic brain biopsy device in the dog. 10 canine cadavers with 20 target points were used to investigate the accuracy. First specific bone anchors and MRI-markers were fixed on dog cadaver heads. Afterwards CT and MRI examinations of the heads were performed. Based on MR-images, patient-individual frames to reach defined target points were constructed and printed with 3D-printer. Two target points were marked in each brain MRI: left caudate nucleus and right piriform lobe. Also trajectories for biopsy needle were plotted on MR-images. The needle was to enter the brain in a gyrus and not to penetrate the ventricles. The frames were fixed on the bone anchors with specific screws. Minimal-invasive access to the brain was created with help of the tool guide. The biopsy needle was placed along pre-planned trajectories. Afterwards CT examinations of the heads with biopsy needles placed in each target point were performed. Needle placement error was determined after fusion of MRI and CT examinations. Error was defined in mm as deviation between achieved and anticipated target points. The deviation of 20 target points revealed mean needle placement error of 0.58 mm (SD 0.34). Therefore, MRI-based patient-individual stereotactic brain biopsy device reaches higher accuracy than most other described brain biopsy systems.