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Measurements of dermal uptake of nicotine directly from air and clothing

 
: Bekö, G.; Morrison, G.; Weschler, C.J.; Koch, H.M.; Salthammer, T.; Schripp, T.; Toftum, J.; Clausen, G.

Kenhove, Elisa van (Hrsg.) ; International Society of Indoor Air Quality and Climate -ISIAQ-, Ottawa:
14th International Conference on Indoor Air Quality and Climate, Indoor Air 2016. Vol.4 : Ghent, Belgium, 3-8 July 2016
Red Hook, NY: Curran, 2016
ISBN: 978-1-5108-3687-7
S.2303-2304
International Conference on Indoor Air Quality and Climate (Indoor Air) <14, 2016, Ghent>
Englisch
Konferenzbeitrag
Fraunhofer WKI ()
exposure pathway; biomonitoring; indoor environment; e-cigarettes

Abstract
Dermal uptake directly from air is a significant contributor to total exposure for certain organic compounds, and has been recently experimentally verified for two phthalates. The objective of the current study was to investigate whether airborne nicotine can be dermally absorbed. Two bare-skinned subjects together with a subject wearing clean clothes were dermally exposed to environmental tobacco smoke (ETS) for three hours in a climate chamber; during the exposure all three subjects breathed clean air through hoods covering their heads. The clothed subject later repeated his exposure wearing a shirt previously exposed to tobacco smoke. Urine samples were subsequently analyzed for nicotine and two of its metabolites. The results demonstrate that nicotine can be dermally absorbed directly from air atrates comparable to passive smoking. Wearing clean clothes significantly decreases uptake, while wearing exposed clothes results in substantial uptake.

: http://publica.fraunhofer.de/dokumente/N-462071.html