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AMP-activated Protein Kinase Suppresses Arachidonate 15-Lipoxygenase Expression in Interleukin 4-polarized Human Macrophages

: Namgaladze, D.; Snodgrass, R.G.; Angioni, C.; Grossmann, N.; Dehne, N.; Geisslinger, G.; Brüne, B.

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The Journal of biological chemistry 290 (2015), Nr.40, S.24484-24494
ISSN: 0021-9258
ISSN: 1083-351X
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer IME ()

Background: How AMP-activated protein kinase (AMPK) influences IL-4-induced human macrophage polarization is not completely understood.

Results: AMPK prevents arachidonate 15-lipoxygenase induction by IL-4 and abolishes the formation of 15-lipoxygenase arachidonic acid metabolites.

Conclusion: AMPK activation promotes an anti-inflammatory phenotype in IL-4-stimulated macrophages by reducing arachidonate 15-lipoxygenase expression.

Significance: This study supports an anti-inflammatory effect of AMPK activation.