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Hydroxyapatite-modified gelatin bioinks for bone bioprinting

: Wenz, Annika; Janke, Katharina; Hoch, Eva; Tovar, Günter; Borchers, Kirsten; Kluger, Petra


Bionanomaterials 17 (2016), Nr.3-4, S.179-184
ISSN: 2193-0651
ISSN: 2193-066X
Fraunhofer IGB ()
additive manufacturing; mineralization; osteoblast differentiation; tissue engineering

In bioprinting approaches, the choice of bioink plays an important role since it must be processable with the selected printing method, but also cytocompatible and biofunctional. Therefore, a crosslinkable gelatin-based ink was modified with hydroxyapatite (HAp) particles, representing the composite buildup of natural bone. The inks’ viscosity was significantly increased by the addition of HAp, making the material processable with extrusion-based methods. The storage moduli of the formed hydrogels rose significantly, depicting improved mechanical properties. A cytocompatibility assay revealed suitable ranges for photoinitiator and HAp concentrations. As a proof of concept, the modified ink was printed together with cells, yielding stable three-dimensional constructs containing a homogeneously distributed mineralization and viable cells.