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Coptis japonica Makino extract suppresses Angiogenesis through regulation of cell cycle-related proteins

: Kim, S.H.; Kim, E.-C.; Kim, W.-J.; Lee, M.-H.; Kim, S.-Y.; Kim, T.-J.


Bioscience, biotechnology and biochemistry 80 (2016), Nr.6, S.1095-1106
ISSN: 0916-8451
ISSN: 1347-6947
Yonsei Fraunhofer MDL ()

Angiogenesis, neovascularization from pre-existing vessels, is a key step in tumor growth and metastasis, and anti-angiogenic agents that can interfere with these essential steps of cancer development are a promising strategy for human cancer treatment. In this study, we characterized the anti-angiogenic effects of Coptis japonica Makino extract (CJME) and its mechanism of action. CJME significantly inhibited the proliferation, migration, and invasion of vascular endothelial growth factor (VEGF)-stimulated HUVECs. Furthermore, CJME suppressed VEGF-induced tube formation in vitro and VEGF-induced microvessel sprouting ex vivo. According to our study, CJME blocked VEGF-induced cell cycle transition in G1. CJME decreased expression of cell cycle-regulated proteins, including Cyclin D, Cyclin E, Cdk2, and Cdk4 in response to VEGF.