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Pharmaceutical nanocrystals confined in porous host systems - interfacial effects and amorphous interphases

: Sonnenberger, N.; Anders, N.; Golitsyn, Y.; Steinhart, M.; Enke, D.; Saalwächter, K.; Beiner, M.


Chemical communications 52 (2016), Nr.24, S.4466-4469
ISSN: 0022-4936
ISSN: 0009-241X
ISSN: 1359-7345
Deutsche Forschungsgemeinschaft DFG
SFB TRR 102; BE 2352/4
Fraunhofer IMWS ()

DSC and NMR results prove the existence of an amorphous acetaminophen nanolayer between acetaminophen nanocrystals (form I and form III) and pore walls in controlled porous glasses. This nanolayer controls the surface energy. This finding is highly relevant for approaches towards crystal engineering in nanopores and indicates similarities to the situation during the early stages of crystallization in polymorphic bulk samples.