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Novel findings in pain processing pathways: implications for miRNAs as future therapeutic targets

: Kynast, K.; Russe, O.; Geisslinger, G.; Niederberger, E.


Expert review of neurotherapeutics 13 (2013), Nr.5, S.515-525
ISSN: 1473-7175
ISSN: 1744-8360
Fraunhofer IME ()

miRNAs are small noncoding RNAs that are important players in development, as well as in a number of physiological and pathophysiological processes. Due to their regulatory role in protein expression, it has been assumed that they are associated with peripheral and central sensitization mechanisms in the nervous system after nociceptive insults. However, the study of miRNAs in pain has emerged only recently. First reports mostly focused on miRNA regulations in different pain states while studies examining the functional role of individual miRNAs are only now arising. In this review, the authors summarize the current knowledge and progress in miRNA research in pain and discuss their potential role as therapeutic antinociceptive targets.