Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Single-cell analysis of CTCs with diagnostic precision: Opportunities and challenges for personalized medicine. Review

: Alberter, Barbara; Klein, Christoph A.; Polzer, Bernhard


Expert review of molecular diagnostics 16 (2016), Nr.1, S.25-38
ISSN: 1473-7159
ISSN: 1744-8352
Deutsche Forschungsgemeinschaft DFG
FOR 2127; KL 1233/10-1
Deutsche Forschungsgemeinschaft DFG
SPP 1190; KL 1233/3-1
Deutsche Forschungsgemeinschaft DFG
KL 1233/2-1
Fraunhofer ITEM ()
circulating tumor cells; liquid biopsy; whole-genome amplification; molecular single-cell analysis; CTC cultivation

The generation of variant cancer cells is the major cause of acquired resistance against systemic therapies and consequently, of our inability to cure advanced cancer patients. Circulating tumor cells are gaining increasing clinical attention because they may enable the monitoring cancer progression and adjustment of treatment. In recent years multiple technologies for enrichment, isolation as well as molecular and functional analysis of circulating tumor cells have been developed. Implementation of these technologies in standardized and automated workflows in clinical diagnostics could provide valuable information for real-time monitoring of cancer and eventually new therapeutic strategies for the benefit of patients.