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Label-free and fluorescence biosensing platform using one-dimensional photonic crystal chips

: Michelotti, Francesco; Schmieder, Stefan; Anopchenko, Aleksei; Munzert, Peter; Sinibaldi, A.; Chandrawati, R.; Rana, S.; Sonntag, Frank; Occhicone, A.; Napione, L.; Stevens, M.M.; Maillart, Emmanuel; Hibti, F.-E.; Frydman, C.; Danz, Norbert


Society of Photo-Optical Instrumentation Engineers -SPIE-, Bellingham/Wash.:
Integrated Optics: Devices, Materials, and Technologies XX : San Francisco, California, 15 - 17 February 2016
Bellingham, WA: SPIE, 2016 (Proceedings of SPIE 9750)
Paper 97501D
Conference "Integrated Optics - Devices, Materials, and Technologies" <20, 2016, San Francisco/Calif.>
Fraunhofer IWS ()
Fraunhofer IOF ()
biosensing; luminescence; photonic crystals; surface plasmon polaritons; optical biosensors; optical biosensors; diseases and disorders

The increasing demand for early detection of diseases drives the efforts to develop more and more sensitive techniques to detect biomarkers in extremely low concentrations. Electromagnetic modes at the surface of one dimensional photonic crystals, usually called Bloch surface waves, were demonstrated to enhance the resolution and constitute an attractive alternative to surface plasmon polariton optical biosensors. We report on the development of Bloch surface wave biochips operating in both label-free and fluorescence modes and demonstrate their use in ovalbumin recognition assays.