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Exogenous application of glucose induces aging in rat cerebral oligodendrocytes as revealed by alteration in telomere length

 
: Dabouras, V.; Rothermel, A.; Reininger-Mack, A.; Wien, S.L.; Layer, P.G.; Robitzki, A.A.

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Neuroscience letters 368 (2004), Nr.1, S.68-72
ISSN: 0304-3940
Englisch
Zeitschriftenaufsatz
Fraunhofer IBMT ()

Abstract
To investigate aspects of aging on rat oligodendrocytes, cells of an oligodendrocyte cell line, so-called OLN-93, were cultured either in the presence or absence of glucose. Our data demonstrated that glucose-induced aging in vitro caused an elongation and thickening of cell processes and significantly increased the expression of netrin reflecting a more mature state of oligodendrocyte development. A possible age-inducing effect of glucose is also supported by the decrease of ras protein expression and shortening of telomeres in glucose-treated oligodendrocytes. The present study clearly shows that OLN-93 cells are an exciting and suitable model system for the investigation of age-inducing molecules and the analysis of signaling pathways involved in cerebral aging and degenerations.

: http://publica.fraunhofer.de/dokumente/N-37528.html