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Analysis of patient groups and immunization results based on subspace clustering

: Hund, M.; Sturm, W.; Schreck, T.; Ullrich, T.; Keim, D.; Majnaric, L.; Holzinger, A.


Guo, Y.:
Brain informatics and health. 8th international conference, BIH 2015 : London, UK, August 30 - September 2, 2015; Proceedings
Cham: Springer International Publishing, 2015 (Lecture Notes in Computer Science 9250)
ISBN: 978-3-319-23343-7 (Print)
ISBN: 978-3-319-23344-4 (Online)
International Conference on Brain Informatics and Health (BIH) <8, 2015, London>
Fraunhofer Austria ()
Business Field: Visual decision support; Research Area: Human computer interaction (HCI); visual analytic; health aspect; data analysis; cluster analysis; clustering

Biomedical experts are increasingly confronted with what is often called Big Data, an important subclass of high-dimensional data. High-dimensional data analysis can be helpful in finding relationships between records and dimensions. However, due to data complexity, experts are decreasingly capable of dealing with increasingly complex data. Mapping higher dimensional data to a smaller number of relevant dimensions is a big challenge due to the curse of dimensionality. Irrelevant, redundant, and conflicting dimensions affect the effectiveness and efficiency of analysis. Furthermore, the possible mappings from high-to low-dimensional spaces are ambiguous. For example, the similarity between patients may change by considering different combinations of relevant dimensions (subspaces). We show the potential of subspace analysis for the interpretation of high-dimensional medical data. Specifically, we analyze relationships between patients, sets of patient attributes, and outcomes of a vaccination treatment by means of a subspace clustering approach. We present an analysis workflow and discuss future directions for high-dimensional (medical) data analysis and visual exploration.