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Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling

: Valle, Jaione; Burgui, Saioa; Langheinrich, Denise; Gil, Carmen; Solano, Cristina; Toledo-Arana, Alejandro; Helbig, Ralf; Lasagni, Andrés-Fabián; Lasa, Iñigo


Macromolecular bioscience 15 (2015), Nr.8, S.1060-1069
ISSN: 1616-5187
Deutsche Forschungsgemeinschaft DFG
LA-2513 4-1
Mechanically stable anti-adhesive polymer surfaces
Fraunhofer IWS ()
adhesion; Biofilm; biomaterial-associated infection; direct laser interference patterning; staphylococcus aureus

Modification of the biomaterial surface topography is a promising strategy to prevent bacterial adhesion and biofilm formation. In this study, we use direct laser interference patterning (DLIP) to modify polystyrene surface topography at sub-micrometer scale. The results revealed that three-dimensional micrometer structures have a profound impact on bacterial adhesion. Thus, line- and pillar-like patterns enhanced S. aureus adhesion, whereas complex lamella microtopography reduced S. aureus adhesion in static and continuous flow culture conditions. Interestingly, lamella-like textured surfaces retained the capacity to inhibit S. aureus adhesion both when the surface is coated with human serum proteins and when the material is implanted subcutaneously in a foreign-body associated infection model.