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Microstructured thermoresponsive polymer coatings as a promising tool for controlling neurite outgrowth in artificial neuronal networks

 
: Kirschbaum, M.; Boerner, G.; Uhlig, K.; Duschl, C.

Zengerle, R. ; Chemical and Biological Microsystems Society -CBMS-, San Diego/Calif.:
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Vol.3 : Freiburg, Germany, 27 - 31 October 2013
Red Hook, NY: Curran, 2014
ISBN: 978-1-63266-624-6
ISBN: 978-0-9798064-6-9 (andere Ausgabe 2013)
S.1707-1709
International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS) <17, 2013, Freiburg/Brsg.>
Englisch
Konferenzbeitrag
Fraunhofer IBMT ()

Abstract
Despite extensive research worldwide, the spatial and temporal control of neurite outgrowth in artificial neuronal networks is still unsolved. Here, we evaluated the potential of thermoresponsive polymer (TRP) coatings as a neuronal cell culture substrate that could allow for elegantly switching on and off neurite pathways by application of simple temperature cues. Immunochemical and morphological analysis of human SH-SY5Y neuroblastoma cells that had been differentiated on TRP coatings demonstrated a high biocompatibility of our substrates. By precisely controlling the temperature of microstructured TRP coatings, we managed to pattern the cells and were able to precisely trigger neurite outgrowth.

: http://publica.fraunhofer.de/dokumente/N-350743.html