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Metabolism of a nonylphenol isomer by Sphingomonas sp. strain TTNP3

 
: Corvini, P.F.X.; Elend, M.; Hollender, J.; Ji, R.; Preiss, A.; Vinken, R.; Schäffer, A.

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Environmental chemistry letters 2 (2005), Nr.4, S.185-189
ISSN: 1610-3653
Englisch
Zeitschriftenaufsatz
Fraunhofer ITEM ()
Fraunhofer IME ()
nonylphenol; single isomer; alkoxyphenol; degradation; sphingomonas; endocrine disruptor; Metabolites

Abstract
For elucidation of the metabolism of the endocrine disruptor nonylphenol by Sphingomonas sp. strain TTNP3, the degradation of an isomer of nonylphenol, 4(2prime,6prime-dimethyl-2prime-heptyl)-phenol, has been studied. As in the case of 4(3prime,5prime-dimethyl-3prime-heptyl)-phenol, the metabolism of this nonylphenol isomer leads to the formation of the NIH-shifted product 2(2prime,6prime-dimethyl-2prime-heptyl)-1,4-benzenediol (NIH: National Institute of Health), but also to the alkoxy derivative 4(2prime,6prime-dimethylheptan-2prime-yloxy)phenol as additional metabolite. To the best of our knowledge, this is the first report describing the formation of alkoxyphenol as a degradation product of nonylphenol. Additionally, these results provide for the first time evidence for slight differences in the biodegradation of the isomers of nonylphenol.

: http://publica.fraunhofer.de/dokumente/N-34705.html