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Water extract of Cinnamomum cassia suppresses angiogenesis through inhibition of VEGF receptor 2 phosphorylation

 
: Kim, E.C.; Kim, H.J.; Kim, T.J.

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Bioscience, biotechnology and biochemistry 79 (2015), Nr.4, S.617-624
ISSN: 0916-8451
ISSN: 1347-6947
Englisch
Zeitschriftenaufsatz
Yonsei Fraunhofer MDL ()

Abstract
Angiogenesis, the process of new blood vessel formation, has been a major target for cancer therapy. Antiangiogenic herbal medicines are useful in the treatment of cancer. In this study, we found that a water extract of Cinnamomum cassia (CCWE) was a potent inhibitor of angiogenesis. In cultured human umbilical vein endothelial cells, CCWE suppressed vascular endothelial growth factor (VEGF)-induced proliferation, migration, invasion, tube formation, and intracellular signaling events such as phosphorylation of ERK, p38 and VEGFR2, and activation of matrix metalloproteinase. Furthermore, CCWE inhibited VEGF-induced vessel sprouting of rat aorta ex vivo. These findings might be of particular interest for drug development because VEGF signaling is a potential target for treatment of angiogenesis-associated diseases.

: http://publica.fraunhofer.de/dokumente/N-343549.html