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Toxicogenomics applied to cardiovascular toxicity

: Thum, T.; Borlak, J.


Borlak, J.:
Handbook of toxicogenomics : Strategies and applications
Weinheim: Wiley-VCH, 2005
ISBN: 3-527-30342-1
Aufsatz in Buch
Fraunhofer ITEM ()
Genetic toxicology; Genetics; Proteomics; Gene expression

Toxicogenomics is an emerging discipline that uses genomics tools, including gene expression profiling technologies, to address problems of toxicological significance. Initial results are now available from studies in which toxicogenomic approaches have been applied to cardiovascular toxicity resulting from treatment with certain
drugs or from environmental pollutants. A variety of drugs were shown to have potential for cardiovascular toxicity. Here, we use a classification based on the phenotype of cardiotoxicity caused by a certain drug and include, whenever available, results from recent toxicogenomic or toxicoproteomic approaches applied to cardiovascular
toxicity. We also discuss the impact of environmental pollutants, such as halogenated aromatic hydrocarbons, on the onset of cardiovascular toxicity. Finally, the importance of genetic polymorphisms and tissue-specific metabolism in cardiovascular drug therapy and toxicity is discussed.