Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Antibody- and aptamer-strategies for GvHD prevention

: Oelkrug, Christopher; Sack, Ulrich; Boldt, Andreas; Nascimento, Isis C.; Ulrich, Henning; Fricke, Stefan


Journal of cellular and molecular medicine 19 (2015), Nr.1, S.11-20
ISSN: 1582-4934
ISSN: 1582-1838
Fraunhofer IZI ()
antibody; Aptamer; GvHD; GvL; murine model; transplantation

Prevention of Graft-versus-Host-Disease (GvHD) by preserved Graft-versus-Leukaemia (GvL) effect is one of the major obstacles following allogeneic haematopoietic stem cell transplantation. Currently used drugs are associated with side effects and were not able to separate GvHD from the GvL-effect because of general T-cell suppression. This review focuses on murine models for GvHD and currently available treatment options involving antibodies and applications for the therapeutic use of aptamers as well as strategies for targeting immune responses by allogenic antigens.