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Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: Results of a double-blinded randomized cross-over clinical pilot study

: Schaumann, Frank; Frömke, Cornelia; Dijkstra, Dorothea; Alessandrini, Francesca; Windt, Horst; Karg, Erwin; Müller, Meike; Winkler, Carla; Braun, Armin; Koch, Armin; Hohlfeld, Jens Michael; Behrendt, Heidrun; Schmid, Otmar; Koch, Wolfgang; Schulz, Holger; Krug, Norbert

Volltext urn:nbn:de:0011-n-3073030 (545 KByte PDF)
MD5 Fingerprint: f2a926990a820fb0e93f4231e4c7c512
Erstellt am: 25.9.2014

Particle and Fibre Toxicology 11 (2014), Art. 39, 21 S.
ISSN: 1743-8977
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer ITEM ()
ultrafine particles; pulmonary inflammation; aerosol exposure; Aeroallergen; Asthma

Epidemiological and experimental studies suggest that exposure to ultrafine particles (UFP) might aggravate the allergic inflammation of the lung in asthmatics.
We exposed 12 allergic asthmatics in two subgroups in a double-blinded randomized crossover design, first to freshly generated ultrafine carbon particles (64
For the entire study group, inhalation of UFP by itself had no significant effect on the allergen induced inflammatory response measured with total cell count as compared to exposure with filtered air (p = 0.188). However, the subgroup of subjects, which inhaled UFP during the first exposure, exhibited a significant increase in total BAL cells (p = 0.021), eosinophils (p = 0.031) and monocytes (p = 0.013) after filtered air exposure and subsequent allergen challenge 28 days later. Additionally, the potential of BAL cells to generate oxidant radicals was significantly elevated at that time point. The subgroup that was exposed first to filtered air and 28 days later to UFP did not reveal differences between sessions.
Our data demonstrate that pre-allergen exposure to UFP had no acute effect on the allergic inflammation. However, the subgroup analysis lead to the speculation that inhaled UFP particles might have a long-term effect on the inflammatory course in asthmatic patients. This should be reconfirmed in further studies with an appropriate study design and sufficient number of subjects.