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Atypical RNAs in the coelacanth transcriptome

 
: Nitsche, A.; Doose, G.; Tafer, H.; Robinson, M.; Saha, N.R.; Gerdol, M.; Canapa, A.; Hoffmann, S.; Amemiya, C.T.; Stadler, P.F.

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Journal of experimental zoology. Part B, Molecular and developmental evolution 322 (2014), Nr.6, S.342-351
ISSN: 0022-104X
ISSN: 1552-5007
ISSN: 1552-5015
European Commission EC
FP7-KBBE; 222664; QUANTOMICS
Bundesministerium für Bildung und Forschung BMBF
01KU1002J
Englisch
Zeitschriftenaufsatz
Fraunhofer IZI ()

Abstract
Circular and apparently trans-spliced RNAs have recently been reported as abundant types of transcripts in mammalian transcriptome data. Both types of non-colinear RNAs are also abundant in RNA-seq of different tissue from both the African and the Indonesian coelacanth. We observe more than 8,000 lincRNAs with normal gene structure and several thousands of circularized and trans-spliced products, showing that such atypical RNAs form a substantial contribution to the transcriptome. Surprisingly, the majority of the circularizing and trans-connecting splice junctions are unique to atypical forms, that is, are not used in normal isoforms.

: http://publica.fraunhofer.de/dokumente/N-307103.html