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Targeted polymeric nanoparticles containing gold nanorods: A therapeutic approach against glioblastoma

: Locatelli, E.; Bost, W.; Fournelle, M.; Llop, J.; Gil, L.; Arena, F.; Lorusso, V.; Comes Franchini, M.


Journal of nanoparticle research 16 (2014), Nr.3, Art. 2304
ISSN: 1388-0764
ISSN: 1572-896X
Fraunhofer IBMT ()

Chlorotoxin-targeted polymeric nanoparticles containing entrapped gold nanorods as potential therapeutic agent for glioblastoma multiforme have been developed and evaluated. In first proof of concept experiments, in vitro specific uptake in cancer cells and selective laser-induced cell death have been shown. In vivo studies with optical imaging showed increased retention of targeted NPs in the tumor.