Fraunhofer-Gesellschaft

Publica

Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Assessment of Perfusion Deficits in Ischemic Stroke Using 3D-GRASE Arterial Spin Labeling Magnetic Resonance Imaging with Multiple Inflow Times

 
: Wolf, M.E.; Layer, V.; Gregori, J.; Griebe, M.; Szabo, K.; Gass, A.; Hennerici, M.G.; Günther, M.; Kern, R.

:

Journal of Neuroimaging 25 (2013), Nr.5, S.453–459
ISSN: 1051-2284
ISSN: 1552-6569
Englisch
Zeitschriftenaufsatz
Fraunhofer MEVIS ()

Abstract
BACKGROUND AND PURPOSE: Arterial spin labeling (ASL) MRI provides information on tissue perfusion by consecutive readout of labeled blood captured in arteries or the microvasculature without using contrast agents. METHODS: We used a single-shot 3D acquisition and readout technique for ASL with multiple inflow times (TI) to evaluate hemodynamic compromise and dynamics of arterial blood inflow expressed by the bolus arrival time (BAT). Thirty-six patients with ischemic stroke were examined with a standard multimodal MRI protocol including dynamic susceptibility contrast (DSC) and multi-TI ASL perfusion imaging. Time-to-peak maps were used to classify hemodynamic impairment as either hypo- or hyperperfusion. RESULTS: Overall there was a good agreement of ASL perfusion maps with DSC perfusion imaging on visual analysis. Correlations were found between ASL-BAT/(DSC-)Mean transit time (MTT) (r = .416; P < .01) and ASL-CBF/MTT (r = -.489; P < .01). Using ASL, BAT in ischemic t erritory was delayed by 55% (P = .001) in patients with hypoperfusion (n = 28); CBF was reduced by 39% (P.001). All patients with hyperperfusion (n = 6) had higher CBF on ASL. CONCLUSIONS: The use of ASL with multiple TI allows the contrast-free assessment of hemodynamic impairment in ischemic stroke patients. Quantitative ASL perfusion analysis reliably demonstrates areas of delayed BAT and reduced CBF matching findings of DSC.

: http://publica.fraunhofer.de/dokumente/N-300893.html