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Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4

: Kolenko, P.


Acta crystallographica. Section F, Structural biology and crystallization communications online 69 (2013), Nr.4, S.358-361
ISSN: 1744-3091
ISSN: 2053-230X (Online)
Fraunhofer IZI ()
drosophila melanogaster; Glutaminyl cyclase; soaking

The structure of ligand-free glutaminyl cyclase (QC) from Drosophila melanogaster (DmQC) has been determined in a novel crystal form. The protein crystallized in space group I4, with unit-cell parameters a = b = 122.3, c = 72.7 Å. The crystal diffracted to a resolution of 2 Å at the home source. The structure was solved by molecular replacement and was refined to an R factor of 0.169. DmQC exhibits a typical [alpha]/[beta]-hydrolase fold. The electron density of three monosaccharides could be localized. The accessibility of the active site will facilitate structural studies of novel inhibitor-binding modes.