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Ultrasound-induced sonoporation with the aid of magnetic nanoparticles

: Anastasiadis, P.; Allen, J.S.; Matsunaga, T.; Bertram, J.; Weber, P.K.; Moisyadi, S.


IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society:
IEEE International Ultrasonics Symposium, IUS 2012 : 7-10 Oct. 2012, Dresden
New York, NY: IEEE, 2012
ISBN: 978-1-4673-4561-3 (Print)
International Ultrasonics Symposium (IUS) <2012, Dresden>
Fraunhofer IBMT ()

Targeted gene and drug delivery has untapped potential for the treatment of a wide range of pathological conditions. The recent advancements in ultrasound contrast agents (UCAs) including their ability to target regions of interest (ROI) with high specificity makes them ideal for a range of both in vitro and in vivo studies. This work investigates gene expression enhancement by a novel combination of nanosized magnetic particles (MagTag®) and cationic UCAs (cUCAs). The cUCAs have been studied alone and in combination with the MATra-A reagent (Iba Life Sciences, Goettingen, Germany), that uses activated magnetic fields for the delivery of nucleic acids into the cell nucleus.