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2008
Conference Paper
Titel
Inducing in vitro angiogenesis for the generation of vascularized scaffolds
Abstract
We developed methods to generate a biological vascularised scaffold [1] and induce angiogenesis in vitro [2]. This vascularised matrix enables the generation of a functional artificial vascular network. Standardization of co-cultures on this vascularized biological matrix should overcome the problem of lacking graft vascularisation and permitting the generation of complex bioartificial organ-like tissues in vitro. This model offers the possibility to study in vitro angiogenesis of human endothelial cells. The generated bioartificial tissues serve as test systems for pharmaceutical drug screening and patient specific therapy [3]. Target screening requires testsystems that mimic the human tissues with increasing accuracy in order to optimize the selection of potential effectors. Our vascularised bioartificial tissues offers the first time the simulation of physiological drug application, studies regarding biotransformation and toxic metabolites, and the establishment nano materials/drug delivery systems for research and therapy. First clinical applications addressed fundamental issues regarding ECM remodelling, functionality and thrombogenity of the vascular network [4].
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