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Sequence error storms and the landscape of mutations in cancer

: Kirsch, S.; Klein, C.A.


Proceedings of the National Academy of Sciences of the United States of America : PNAS 109 (2012), Nr.36, S.14289-14290
ISSN: 0027-8424
ISSN: 1091-6490
Fraunhofer ITEM ()
complementary DNA; transcriptome; cancer genetics; DNA sequence; sequence analysis; RNA analysis; gene mutation; breast - cancer

Next-generation sequencing (NGS) has revolutionized genome and transcriptome analyses in recent years. Now, a smart and simple modification termed duplex sequencing published in PNAS by Schmitt et al. (1) may pave the way to explore the full power of NGS in answering fundamental questions and particularly through its application to cancer research. This enthusiasm is warranted because duplex sequencing reportedly reduces the error rate of NGS up to 10 million-fold.