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Novel insights into the role of S100A8/A9 in skin biology

: Kerkhoff, C.; Voss, A.; Scholzen, T.E.; Averill, M.M.; Zanker, K.S.; Bornfeldt, K.E.


Experimental dermatology 21 (2012), Nr.11, S.822-826
ISSN: 0906-6705
ISSN: 1600-0625
Fraunhofer IZI ()

S100A8 and S100A9 belong to the damage-associated molecular pattern molecules. They are upregulated in a number of inflammatory skin disorders. Owing to their abundance in myeloid cells, the main function of S100A8/A9 has been attributed to their role in inflammatory cells. However, it is becoming increasingly clear that they also exert important roles in epithelial cells. In this review, we discuss the context-dependent function of S100A8/A9 in epithelial cells and their impact on wound healing, psoriasis and other skin diseases.