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Automatic image quantification for structural analysis of in vitro dermal samples

: Gryanik, Alexander; Wittenberg, Thomas; Walles, Heike; Steckhan, Dirk; Thude, Sibylle; Kaufmann, Michaela; Münzenmayer, Christian

Deutsche Gesellschaft für Biomedizinische Technik -DGBMT-; Univ. Freiburg/Brsg., Institut für Mikrosystemtechnik -IMTEK-:
BMT 2012, Biomedizinische Technik. Proceedings 46. DGBMT Jahrestagung : Jena, September 16 - 19, 2012
Berlin: De Gruyter, 2012 (Biomedizinische Technik 57, 2012, Supplement 1)
S.494-497, Track B
Deutsche Gesellschaft für Biomedizinische Technik (DGBMT Jahrestagung) <46, 2012, Jena>
Konferenzbeitrag, Zeitschriftenaufsatz
Fraunhofer IIS ()
Fraunhofer IGB ()

Artificial skin substitutes display similar physical, chemical and histological characteristics as real human skin. This property can be used for in vitro cosmetic product testing, drug discovery as well as toxicity screening in the fields of medicine, development of cosmetic and toxic products, health care and biomedical research. Specifically, to analyze and visualize toxic effects on tissue-engineered skin we have developed a prototypical microscopy-based scanning and analysis system in order to provide more efficient, standardized and reproducible measurements. Within this contribution we will briefly describe the image acquisition approach and focus on the localization, segmentation and classification of histologically stained skin samples, with focus on the epidermis. The results obtained from our system are compared to ground truth data.