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Simulation and Visualization of Medical Application to the Inner Ear of the Guinea Pig to Reduce Animal Experiments

: Hering-Bertram, M.; Siedow, N.; Tse, O.; Plontke, S.; Gill, R.

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Hagen, H.:
Scientific visualization : interactions, features, metaphors
Dagstuhl: Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2011 (Dagstuhl follow-ups 2)
ISBN: 978-3-939897-26-2
Seminar "Scientific Visualization: Interactions, Features, Metaphors" <2009, Schloß Dagstuhl/Wadern>
Elektronische Publikation, Konferenzbeitrag
Fraunhofer ITWM ()
Cochlea; Perilymph; Spiral Ligament; Round Window Application; Modiolar Communication Routes; Numerical Simulation; Parameter Identification

We present a novel approach to simulate drug application to the inner ear of the guinea pig with the goal to reduce animal experiments and to increase the accuracy of measurements. The framework is based on a tetrahedral grid representing the individual compartments of the cochlea, associated with a finite element model used to simulate medical diffusion and clearance. In a first simulation scenario, we were able to compute transfer coefficients between the inner compartments of the ear, validating experiments from the literature, and to prove the existence of clearance at the inner scala tympani. In a second scenario, the cochlea was unwound to obtain a one-dimensional model for efficient simulation-based transfer coefficient identification. These coefficients are useful to predict the impact of novel medication application systems.