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The human adenosine A2B receptor : Homology modeling, virtual screening, and computer-aided drug design

 
: Selim, F.F.S.

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Volltext (PDF; )

Bonn, 2011, XX, 189 S.
Bonn, Univ., Diss., 2011
URN: urn:nbn:de:hbz:5N-24220
Englisch
Dissertation, Elektronische Publikation
Fraunhofer SCAI ()

Abstract
The adenosine A2B receptor belongs to the class A of G protein-coupled receptors. It is playing a crucial role in cell signalling and various physiological responses. The adenosine A2B receptor, a promising target in the challenge of improving human health, was and will be an important subject in the pharmacological research field. However, the X-ray structure of the adenosine A2B receptor has still not yet been resolved. Therefore, variants of a 3D homology model of the adenosine A2B receptor were generated using the crystal structures of the three related GPCRs (bovine rhodopsin, the ?2-adrenergic receptor and the adenosine A2B receptor) as templates in order to proceed with looking into binding behaviour of antagonists and agonists by computational methods.

: http://publica.fraunhofer.de/dokumente/N-219585.html