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The role of nacreous factors in preventing osteoporotic bone loss through both osteoblast activation and osteoclast inactivation

: Kim, H.; Lee, K.; Ko, C.Y.; Kim, H.S.; Shin, H.I.; Kim, T.; Lee, S.H.; Jeong, D.


Biomaterials 33 (2012), Nr.30, S.7489-7496
ISSN: 0142-9612
ISSN: 1878-5905
Fraunhofer IZFP, Institutsteil Dresden ( IKTS-MD) ()

Excessive bone resorption by osteoclasts relative to bone formation by osteoblasts results in the development of osteoporosis. Anti-osteoporotic agents that are able both to inhibit bone resorption and to stimulate bone formation are not available. We now show that water-soluble nacreous factors prepared from the pearl oyster Pteria martensii prevent osteoporotic bone loss associated with estrogen deficiency in mice mainly through osteoclast inactivation. Nacreous factors stimulated osteoblast bio-mineralization in vitro in association with activation of signaling by c-Jun NH2-terminal kinase (JNK) and Fos-related antigen-1 (Fra-1). They also suppressed both osteoclast formation by blocking up-regulation of nuclear factor of activated T cells cytoplasmic 1 (NFATc1) as well as bone pit formation mediated by mature osteoclasts, likely by disrupting the actin ring of these cells. Our findings thus show that the components of a natural material have beneficial effects on bone remodeling that are mediated through regulation of both osteoblast and osteoclast function. They may thus provide a basis for the development of biomimetic bone material as well as anti-osteoporotic agents.