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In vitro study revealed different size behavior of different nanoparticles

: Schaudien, D.; Knebel, J.; Creutzenberg, O.


Journal of nanoparticle research 14 (2012), Nr.8, Art. 1039, 9 S.
ISSN: 1388-0764
ISSN: 1572-896X
Fraunhofer ITEM ()
air-liquid interface culture; nanoparticle; in vitro

Toxicity of nanoparticles is depending not only on the size of the primary particles but on the size of their agglomerates. Therefore, further studies are needed to examine the behavior of nanoparticles after they have gotten in contact with cells. The presented study investigated the change of size of different commercially available nanoparticles after applying them to different cell lines such as A549, Calu-3, 16HBE14o and LK004 representative for the different parts of the human lung. The different nanoparticles exhibited differences in behavior of size. TiO2 P25 showed a tendency to increase, whereas TiO2 T805 and Printex (R) 90 remained more or less at the same size. In contrast, ZnO < 50 nm particles showed a significant decrease of size.