Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Identification of temperature-dependent parameters in laser-interstitial thermo therapy

: Tse, O.; Pinnau, R.; Siedow, N.


Mathematical models & methods in applied sciences 22 (2012), Nr.9, Art.1250019
ISSN: 0218-2025
Fraunhofer ITWM ()

Laser-induced thermotherapy (LITT) is an established minimally invasive percutaneous technique of tumor ablation. Nevertheless, there is a need to predict the effect of laser applications and optimize irradiation planning in LITT. Optical attributes (attenuation, absorption, scattering) change due to thermal denaturation. The work presents the possibility to identify these temperature-dependent parameters from given temperature measurements via an optimal control problem. The solvability of the optimal control problem is analyzed and results of successful implementations are shown.