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International harmonization of toxicologic pathology nomenclature

An overview and review of basic principles
 
: Mann, P.C.; Vahle, J.; Keenan, C.M.; Baker, J.F.; Bradley, A.E.; Goodman, D.G.; Harada, T.; Herbert, R.; Kaufmann, W.; Kellner, R.; Nolte, T.; Rittinghausen, S.; Tanaka, T.

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Toxicologic Pathology 40 (2012), Nr.4, S.7-13
ISSN: 0192-6233
ISSN: 1533-1601
Englisch
Zeitschriftenaufsatz
Fraunhofer ITEM ()
Animals; mouse; Rats; neoplasms; toxicity tests; pathology; toxicology

Abstract
The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice is a global project that is publishing criteria for both proliferative and nonproliferative changes in laboratory animals. This paper presents a set of general suggestions for terminology across systems. These suggestions include the use of diagnostic versus descriptive terms, modifiers, combination terms, and grading systems; and the use of thresholds, synonyms, and terminology for some processes that are common to several organ systems. The purpose of this paper is to help the reader understand some of the basic principles underlying the International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice process.

: http://publica.fraunhofer.de/dokumente/N-211665.html