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Changes in T2 relaxation time after stroke reflect clearing processes

 
: Wagner, Daniel-Christoph; Deten, Alexander; Härtig, Wolfgang; Boltze, Johannes; Kranz, Alexander

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NeuroImage 61 (2012), Nr.4, S.780-785
ISSN: 1053-8119
ISSN: 1095-9572
Englisch
Zeitschriftenaufsatz
Fraunhofer IZI ()
cerebral ischemia; magnetic resonance imaging; inflammation; necrosis

Abstract
Background and purpose: CT and MR imaging techniques are frequently used for the diagnosis and progress monitoring of ischemic stroke in clinical practice and research. After stroke, both methods are characterized by a transient pseudo-normalized imaging signal, the so-called fogging phenomenon. This study evaluates potential pathophysiological changes associated with fogging, as well as its influence on the correct determination of the ischemic lesion in a rat stroke model.
Methods: Male spontaneously hypertensive rats were subjected to permanent middle cerebral artery occlusion. Ischemic lesion volume, brain edema and gray scale value spread within the ischemic lesion were determined on T2-weighted MR sequences at days 1, 4, 8, 11 and 29 after stroke onset, and compared with immunohistochemistry for astrogliosis, microglia/macrophage infiltration and angiogenesis.
Results: All animals showed MR fogging at days 4, 8 and 11 after stroke. The transient normalization of T 2 signals occurred independently from the development of infarct volumes, but coincided well with the spatio-temporal occurrence of necrosis, angiogenesis and microglia/macrophage infiltration.
Conclusions: Our results suggest that the fogging effect reflects the clearance of necrotic tissue within the ischemic lesion and is thus not relevant for the determination of the lesion volume.

: http://publica.fraunhofer.de/dokumente/N-206252.html