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Non-destructive detection of defects in artificial skin tissue by optical coherence tomography

: Schmitt, R.; Marx, U.; Heymer, A.; Kaufmann, M.

Dirckx, J.J.J.:
4th International Conference on Optical Measurement Techniques for Structures & Systems, OPTIMESS 2009. Proceedings : Antwerp, Belgium, 25 - 26 May 2009
Aachen: Shaker, 2009
ISBN: 978-90-423-0366-9
International Conference on Optical Measurement Techniques for Structures & Systems (OPTIMESS) <4, 2009, Antwerp>
Fraunhofer IGB ()

The application of optical coherence tomography (OCT) in tissue engineering facilities offers great potential for the automated detection of defects or inhomogeneities in tissue products. This non-invasive and non-destructive measurement technique allows the high speed generation of two dimensional cross sections of tissue with micron resolution. By the integration into a tissue production facility, the monitoring and quality control of the products will be possible. This allows the selective exclusion of products with insufficient quality from the production chain. In a first study, OCT tomograms of artificial skin equivalents were acquired and compared with microscopic images of associated histologies. As a result, a well-defined analogy of the obtained images is presented. Hence, OCT provides a powerful measurement technique for detecting defects and inhomogeneities in tissue products.