Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

Tumours of the pituitary pars intermedia with associated bilateral adrenocortical hyperplasia in aging male rats

A distinct clinico-pathologic entity resembling Cushing's disease
: Heinrichs, M.; Bube, A.; Ernst, H.; Troschau, G.; Friderichs-Gromoll, S.

Experimental and Toxicologic Pathology 54 (2003), Nr.4, S.354-355
ISSN: 0940-2993
Fraunhofer ITEM ()
Pituitary tumour; Pituitary carcinoma; pars intermedia; adrenocortical hyperplasia; Cushing's disease; adrenocorticotropic hormone; ACTH; POMC; rat; Adrenocortical hormones

An emanciated control mal Wistar rat (Hsd/Cpb:Wu) from an oral gavage carcinogenicity study died on study day 637 and was found at necropsy to have a pituitary mass, extremely large adrenal glands, a swollen, mottled brown-yellow liver, extremely small testes and pododermatitis of the hindlegs.