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Tumours of the pituitary pars intermedia with associated bilateral adrenocortical hyperplasia in aging male rats

A distinct clinico-pathologic entity resembling Cushing's disease
 
: Heinrichs, M.; Bube, A.; Ernst, H.; Troschau, G.; Friderichs-Gromoll, S.

Experimental and Toxicologic Pathology 54 (2003), Nr.4, S.354-355
ISSN: 0940-2993
Englisch
Zeitschriftenaufsatz
Fraunhofer ITEM ()
Pituitary tumour; Pituitary carcinoma; pars intermedia; adrenocortical hyperplasia; Cushing's disease; adrenocorticotropic hormone; ACTH; POMC; rat; Adrenocortical hormones

Abstract
An emanciated control mal Wistar rat (Hsd/Cpb:Wu) from an oral gavage carcinogenicity study died on study day 637 and was found at necropsy to have a pituitary mass, extremely large adrenal glands, a swollen, mottled brown-yellow liver, extremely small testes and pododermatitis of the hindlegs.

: http://publica.fraunhofer.de/dokumente/N-19171.html