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Mitoxantrone-loaded zeolite beta nanoparticles

Preparation, physico-chemical characterization and biological evaluation
 
: Grund, S.; Doussineau, T.; Fischer, D.; Mohr, G.J.

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Journal of colloid and interface science 365 (2012), Nr.1, S.33-40
ISSN: 0021-9797
Englisch
Zeitschriftenaufsatz
Fraunhofer EMFT ()

Abstract
This article describes the preparation and the physico-chemical characterization of a new host-guest system consisting of zeolite beta nanoparticles as host and mitoxantrone as guest. The resulting host-guest system mitoxantrone@. beta is characterized in terms of morphology (transmission electron microscopy, dynamic light scattering), structure (powder wide-angle X-ray diffraction, nitrogen sorption), surface charge (-potential measurements), and optical properties (UV-visible absorption, steady-state fluorescence). Mitoxantrone@. beta particles are monodisperse in size with a mean diameter centered around 100. nm. Mitoxantrone guest molecules are adsorbed at the micropore entrances of zeolite host. Resulting nanoparticles retrieve the interesting optical properties of guest molecules with a fluorescence emission band in the near-infrared region. Mitoxantrone loading is comparatively evaluated by three different means (elemental analysis, direct and indirect UV-visible absorption studies) showing a loading level of 6.8. mol/g. Mitoxantrone@. beta nanoparticles also show a noticeable cytotoxic effect when applied to cancer cells.

: http://publica.fraunhofer.de/dokumente/N-190040.html