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DARIO: a ncRNA detection and analysis tool for next-generation sequencing experiments

: Fasold, Mario; Langenberger, David; Binder, Hans; Stadler, Peter F.; Hoffmann, Steve

Postprint (PDF; )

Nucleic Acids Research 39 (2011), Supplement 2, S.W112-W117
ISSN: 0305-1048
ISSN: 0301-5610
ISSN: 1362-4962
Zeitschriftenaufsatz, Elektronische Publikation
Fraunhofer IZI ()

Small non-coding RNAs (ncRNAs) such as microRNAs, snoRNAs and tRNAs are a diverse collection of molecules with several important biological functions. Current methods for high-throughput sequencing for the first time offer the opportunity to investigate the entire ncRNAome in an essentially unbiased way. However, there is a substantial need for methods that allow a convenient analysis of these overwhelmingly large data sets. Here, we present DARIO, a free web service that allows to study short read data from small RNA-seq experiments. It provides a wide range of analysis features, including quality control, read normalization, ncRNA quantification and prediction of putative ncRNA candidates. The DARIO web site can be accessed at http://dario.bioinf.uni-