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Targeted human serum albumin nanoparticles for specific uptake in EGFR-Expressing colon carcinoma cells

 
: Löw, K.; Wacker, M.; Wagner, S.; Langer, K.; Briesen, H. von

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Nanomedicine. Nanotechnology, biology and medicine 7 (2011), Nr.4, S.454-463
ISSN: 1549-9642
ISSN: 1549-9634
Englisch
Zeitschriftenaufsatz
Fraunhofer IBMT ()

Abstract
The specific application and transport of drugs into malignant tissue is a critical point during diagnosis and therapy. Nanoparticles are known as excellent drug carrier systems and offer the possibility of surface modification with targeting ligands, leading to a specific accumulation in the targeted tissue. First, the specificity of such a carrier system has to be proven. In this study, cetuximab-modified nanoparticles based on biodegradable human serum albumin (HSA) are investigated regarding their cellular binding and intracellular accumulation. Different EGFR-expressing colon carcinoma cells were used to test possible cytotoxic potential, specific binding and intracellular accumulation. A specific accumulation targeting the EGFR could be shown. These results emphasize that cetuximab-modified HSA-nanoparticles are a promising carrier system for later drug transport. To our knowledge, this is the first study investigating the specific accumulation of HSA nanoparticle s into different EGFR-expressing colon carcinoma cells.

: http://publica.fraunhofer.de/dokumente/N-189556.html