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MicroRNA or not microRNA?

: Langenberger, D.; Bartschat, S.; Hertel, J.; Hoffmann, S.; Tafer, H.; Stadler, P.F.


Souza, O.N. de:
Advances in bioinformatics and computational biology : 6th Brazilian Symposium on Bioinformatics, BSB 2011, Brasilia, Brazil, August 10-12, 2011
Berlin: Springer, 2011 (Lecture notes in bioinformatics 6832)
ISBN: 3-642-22824-0
ISBN: 978-3-642-22824-7
ISBN: 978-3-642-22825-4
Brazilian Symposium on Bioinformatics (BSB) <6, 2011, Brasilia>
Fraunhofer IZI ()

The avalanche of next generation sequencing data has led to a rapid increase of annotated microRNAs in the last few years. Many of them are specific to individual species or rather narrow clades. A closer inspection of the current version of miRBase shows that dozens of entries conflict with other ncRNAs, in particular snoRNAs. With few exceptions, these cases show little similarities to canonical microRNAs, however, and thus they should be considered as mis-annotations.