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Enzyme electrode for aromatic compounds exploiting the catalytic activities of microperoxidase-11

: Yarman, A.; Badalyan, A.; Gajovic-Eichelmann, N.; Wollenberger, U.; Scheller, F.W.


Biosensors & bioelectronics 30 (2011), Nr.1, S.320-323
ISSN: 0956-5663
ISSN: 1873-4235
Fraunhofer IBMT ()

Microperoxidase-11 (MP-11) which has been immobilised in a matrix of chitosan-embedded gold nanoparticles on the surface of a glassy carbon electrode catalyzes the conversion of aromatic substances. This peroxide-dependent catalysis of microperoxidase has been applied in an enzyme electrode for the first time to indicate aromatic compounds such as aniline, 4-fluoroaniline, catechol and p-aminophenol. The electrode signal is generated by the cathodic reduction of the quinone or quinoneimine which is formed in the presence of both MP-11 and peroxide from the substrate. The same sensor principle will be extended to aromatic drugs.