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2010
Conference Paper
Titel
Evolution of the long non-coding RNAs MALAT1 and MEN beta/epsilon
Abstract
MALAT1 is one of the best-conserved long ncRNAs in mammals and shares several characteristics, among them nuclear retention and a non-standard processing of its 3' end, with the longer, but less well conserved, adjacent MEN RNA. We show that MALAT1 is conserved among gnathostomes (with the possible exception of birds), while MEN likely originated in the mammalian stem lineage. Evolutionary conserved features of both transcripts are discussed, including RNA secondary structure motifs and short RNA processing products.