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Hollow microneedle electrode arrays for intracellular recording applications

 
: Held, J.; Gaspar, J.; Koester, P.J.; Tautorat, C.; Hagner, M.; Cismak, A.; Heilmann, A.; Baumann, W.; Ruther, P.; Paul, O.

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Institute of Electrical and Electronics Engineers -IEEE-:
IEEE 22nd International Conference on Micro Electro Mechanical Systems, MEMS 2009 : Proceedings of a meeting held 25-29 January 2009, Sorrento, Italy
Piscataway/NJ: IEEE, 2009
ISBN: 978-1-4244-2977-6
ISBN: 978-1-4244-2978-3
S.220-223
International Conference on Micro Electro Mechanical Systems (MEMS) <22, 2009, Sorrento>
Englisch
Konferenzbeitrag
Fraunhofer IWM ()

Abstract
This paper reports on the fabrication of hollow microneedle electrodes with fluidic channels arranged in 8x8 arrays. Features of these electrodes include (i) an increased surface area for improved intracellular potential measurements with simultaneous membrane cell poration capabilities, (ii) their potential use in highly parallel patch-clamp applications and (iii) the ability to efficiently inject reagents and extract cytoplasm into and from the cell interior, respectively. Three different fabrication processes to realize hollow microneedle electrode arrays with incorporated microfluidic components, as well as initial experiments with cell cultures, are presented.

: http://publica.fraunhofer.de/dokumente/N-188404.html