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Non-destructive detection of defects in artificial skin tissue by optical coherence tomography

: Schmitt, R.; Marx, U.; Heymer, A.; Kaufmann, M.


Andersen, P.E.:
Optical coherence tomography and coherence techniques IV : 14 - 17 June 2009, Munich
Bellingham, WA: SPIE, 2009 (Proceedings of SPIE 7372)
ISBN: 978-0-8194-7648-7
ISSN: 1605-7422
Art. 73722F
Conference "Optical Coherence Tomography and Coherence Techniques" <2009, Munich>
Fraunhofer IGB ()

The application of optical coherence tomography OCT in tissue engineering facilities offers great potential for the automated detection of defects or inhomogeneities in tissue products. This non-invasive and non-destructive measurement technique enables the high speed generation of two dimensional cross sections of tissue with micron resolution. The integration of an OCT device into a tissue production facility allows the monitoring and quality control of tissue engineering products. By the selective exclusion of tissue products with insufficient quality features a high degree in production standard is guaranteed. In a first study, OCT tomograms of artificial skin equivalents were acquired and compared with microscopic images of associated histologies. As a result, a well-defined analogy of the obtained images is presented. The most common defect in terms of hole structures that occurs due to a procedural steps could be detected. Further characteristics like the topogra phy, homogeneity and layer structure was analysed. Hence, OCT provides a powerful measurement technique to monitor the quality of tissue products in automated tissue engineering facilities.