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2006
Conference Paper
Titel
In vitro human model for tumor target screening in Cancer research
Abstract
Monolayer and suspension cultures have limited predictive value for target screening especially for nanomaterials. Target screening requires testsystems that mimic the human cancer with increasing accuracy in order to optimize the selection of potential effectors. Tissue engineering is not only the generation of tissues it should also identify biological principles of cellular behaviour. We developed a new 3D vascularised test system with a functional artificial vascular network embedded in a collagen matrix. This bioartificial vascularised matrix can be additional populated with tumor cells to create ex vivo vascularised tumor-like structures. This model offers the possibility to simulate physiological drug application and a human 3D testsystem to established nanomaterials/systems for cancer research/therapy.