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2000
Journal Article
Titel
Kinetische Messungen auf einem DNA-Chip
Alternative
Kinetic measurement on a DNA chip
Abstract
Small deviations in gene sequences are coming in the focus of interest since the influence of SNPs (single nucleotide polymorphisms) on medical therapy is better understood. We now present a detection method for SNPs, which is robust in respect to noisy samples, i.e. variation of DNA concentration or interfering DNA. The method is based on the determination of a characteristic biophysical constant, the dissociation rate constant.