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Surface modification of polymeric microspheres using glycopolymers for biorecognition

 
: Pfaff, A.; Barner, L.; Müller, A.H.E.; Granville, A.M.

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European polymer journal : EPJ 47 (2011), Nr.4, S.805-815
ISSN: 0014-3057
Englisch
Zeitschriftenaufsatz
Fraunhofer ICT ()
Fraunhofer ICT ()

Abstract
We report the synthesis and characterization of sugar-containing microspheres consisting of poly(divinylbenzene) (PDVB) cores onto which chains of galactose- or mannose-bearing polymers have been grafted. PDVB particles prepared by distillation polymerization with a diameter of 2.4 mu m containing residual surface vinyl groups were used as starting material. "Grafting from", "grafting through" and "grafting to" techniques were performed and special interest was laid towards the resulting grafting densities. The surface modification via "grafting from" was conducted by reversible addition fragmentation chain transfer (RAFT) polymerization directly from the surface, whereas thiol-ene chemistry was used to affix glycopolymer chains onto the particle surface. The resulting sugar-covered microspheres were analyzed towards their protein recognition activity with a series of lectins.

: http://publica.fraunhofer.de/dokumente/N-163252.html