Hier finden Sie wissenschaftliche Publikationen aus den Fraunhofer-Instituten.

5D-intravital tomography as a novel tool for non-invasive in-vivo analysis of human skin

: König, K.; Weinigel, M.; Breunig, H.G.; Gregory, A.; Fischer, P.; Kellner-Höfer, M.; Bückle, R.; Schwarz, M.; Riemann, I.; Stracke, F.; Huck, V.; Gorzelanny, C.; Schneider, S.W.


Mahadevan-Jansen, A. ; Society of Photo-Optical Instrumentation Engineers -SPIE-, Bellingham/Wash.:
Advanced biomedical and clinical diagnostic systems VIII : 24 - 26 January 2010, San Francisco, California, United States; SPIE Photonics West
Bellingham, WA: SPIE, 2010 (Proceedings of SPIE 7555)
ISBN: 978-0-8194-7951-8
ISSN: 1605-7422
Paper 75551I
Conference "Advanced Biomedical and Clinical Diagnostic Systems" <8, 2010, San Francisco/Calif.>
Photonics West Conference <2010, San Franciso/Calif.>
Fraunhofer IBMT ()

Some years ago, CE-marked clinical multiphoton systems for 3D imaging of human skin with subcellular resolution have been launched. These tomographs provide optical biopsies with submicron resolution based on two-photon excited autofluorescence (NAD(P)H, flavoproteins, keratin, elastin, melanin, porphyrins) and second harmonic generation by collagen. The 3D tomograph was now transferred into a 5D imaging system by the additional detection of the emission spectrum and the fluorescence lifetime based on spatially and spectrally resolved time-resolved single photon counting. The novel 5D intravital tomograph (5D-IVT) was employed for the early detection of atopic dermatitis and the analysis of treatment effects.