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Type A natriuretic peptides exhibit different bronchoprotective effects in rats

: Flüge, T.; Hoymann, H.-G.; Hohlfeld, J.; Heinrich, U.; Fabel, H.; Wagner, T.O.; Forssmann, W.-G.


European Journal of Pharmacology 271 (1994), Nr.2/3, S.395-402
ISSN: 0014-2999
Fraunhofer ITA ( ITEM) ()
urodilatin; natriuretic peptide; bronchoprotection; Acetylcholine; Pulmonary function tests; rat; lung function

The protective effect of 11.4, 22.8 or 45.6 pmol/kg/min cardiodilatin/atrial natriuretic peptide (CDD/ANP-(99-126)), urodilatin (CDD/ANP-(95-126)) or vehicle intravenously against acetylcholine-induced bronchoconstriction was compared in spontaneously breathing, halothane-anesthetized Wistar rats. The inhalation of acetylcholine induced significant alterations of the spontaneous breathing parameters evaluated by whole-body plethysmography without significant differences between the duced temporary apnoea after the challenge. The forced expiratory volume in 0.1 s revealed a significant protective effect of 11.4 pmol/kg/min urodilatin compared to the controls whereas the parameters of the forced expiratory flow-volume curve were significantly preserved by 11.4 and 22.8 pmol/kg/min urodilatin (P<0.05). Urodilatin showed effects against an acetylcholine challenge whereas CDD/ANP-(99-126) was without significant influence.