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Proliferative and nonproliferative lesions of the rat and mouse respiratory tract

: Renne, R.; Brix, A.; Harkema, J.; Herbert, R.; Kittel, K.; Lewis, D.; March, T.; Nagano, K.; Pino, M.; Rittinghausen, S.; Rosenbruch, M.; Tellier, P.; Wohrmann, T.


Toxicologic Pathology 37 (2009), Nr.7, S.5S-73S
ISSN: 0192-6233
ISSN: 1533-1601
Fraunhofer ITEM ()
gene-related peptide; sprague-dawley rats; Fischer 344 rat; beta-oxidized dipropylnitrosamine; Cytokeratin expression patterns; Tobacco-specific nitrosamine; Titanium-dioxide particles; long-term inhalation; nasal cavity tumor; clara cell adenomas; respiratory system

The INHAND Project (International Harmonization of and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP). Great Britain (BSTP). Japan (JSPT) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the respiratory tract of laboratory rats and mice, with color photomicrographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http.//www gorem org/) Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous developmental and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for respiratory tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.